Use of a loading dose is not recommended in adolescents and children weighing less than 50 kg. The safety and efficacy of lacosamide in children aged below 4 years have not yet been established….Hide table of contents.
| Starting dose | 2 mg/kg/day |
|---|---|
| Maximum recommended dose in patients ≥ 30 kg to < 50 kg | up to 8 mg/kg/day |
How long should VIMPAT be taken?
VIMPAT and VIMPAT injection may be initiated in adult patients with a single loading dose of 200 mg, followed approximately 12 hours later by 100 mg twice daily (200 mg per day). The maintenance dose regimen should be continued for one week. VIMPAT can then be titrated as recommended in Table 1.
Does vimpat have to be taken 12 hours apart?
It is generally given in 2 doses about 12 hours apart. The dose may be increased more slowly in people prone to side effects. The dose can be started more quickly by giving one ‘loading dose’ of 200 mg for the first dose.
What happens if I take too much Vimpat?
Symptoms of overdose may include: severe nausea/vomiting, difficulty waking up, confusion, irregular heartbeat, very slow breathing.
Why can’t vimpat be crushed?
Swallow the tablets whole with a glass of water – do not chew them. They can be crushed and mixed with food if swallowing is a problem, but they may have a bitter taste. Lacosamide is absorbed well from the stomach.
Is Vimpat similar to Keppra?
Are Keppra and Vimpat the Same Thing? Keppra (levetiracetam) and Vimpat (lacosamide) are anti-epileptic drugs (AEDs) (anticonvulsants) often used in conjunction with other drugs to treat types of seizures in people with epilepsy.
What happens if you take too much Vimpat?
What is the duration of treatment for Vimpat?
The clinical study experience of intravenous VIMPAT is limited to 5 days of consecutive treatment. VIMPAT and VIMPAT injection may be initiated in adult patients with a single loading dose of 200 mg, followed approximately 12 hours later by 100 mg twice daily (200 mg per day). This maintenance dose regimen should be continued for one week.
What is the maximum dose of Vimpat for renal failure?
A maximum dose of 300 mg per day VIMPAT is recommended for patients with severe renal impairment [creatinine clearance (CLCR) less than or equal to 30 mL/min] and in patients with endstage renal disease. VIMPAT is effectively removed from plasma by hemodialysis.
How do you increase the dose of Vimpat?
VIMPAT can be increased at weekly intervals by 100 mg/day given as two divided doses up to the recommended maintenance dose of 200 to 400 mg/day, based on individual patient response and tolerability.
What is the volume distribution of Vimpat 10 mg/mL?
In a trial comparing the oral tablet with and an oral solution containing 10 mg/mL lacosamide, bioequivalence between both formulations was shown. The volume of distribution is approximately 0.6 L/kg and thus close to the volume of total body water. VIMPAT is less than 15% bound to plasma proteins.
