Conclusions. In summary, our studies establish that 1) emodin is safe for use in both male and female mice when given at 20, 40, and 80 mg/kg doses for 12 weeks and 2) sex differences should be considered when establishing dosing intervals for emodin treatment.
What are anthraquinone glycosides?
Anthraquinone glycosides are a series of major active ingredients found in all three species. They are key intermediates in the anthraquinone secondary metabolism and the sennnoside biosynthesis. The variation of the anthraquinone glycoside content in rhubarb in response to specific factors remains an attractive topic.
What is aloin content?
The aloin A content was approximately 32, 66, and 98 mg/kg water in the 0.5%, 1.0%, and 1.5% dosed water solutions of Aloe vera whole leaf extract, respectively; aloin B was not measured.
What is Rhein used for?
Rhein, an anthraquinone drug, is a widely used traditional Chinese medicine. Rhein is a major bioactive metabolite of diacerein which has been approved for treating osteoarthritis with a good safety profile in humans.
What foods contain anthraquinone?
Introduction. Anthraquinones (AQs) are found in rhubarb root, Senna leaf and pod, Cascara, Buckhorn, and Aloe, and they are widely used in laxative preparations. AQ laxatives include physcion, chrysophanol, aloe-emodin, rhein, and sennosides.
Which is the example of anthraquinone dye?
Alizarin
Alizarin is an example of anthraquinone dye.
What are the side effects of aloin?
Adverse Effects Aloes is a potent purgative that may cause abdominal pains, gastrointestinal (GI) irritation and in large doses may result in nephritis, bloody diarrhea, and hemorrhagic gastritis.
How much aloin is safe?
The International Aloe Science Council standard suggests that the maximum allowable aloin content in Aloe-derived material for oral consumption is less than 10 ppm (parts per million); for nonmedical use the recommended limit is 50 ppm or lower.
What is the meaning of Rhein?
topographic name for someone who lived by the Rhine river, which is first recorded in the Roman period in the form Rhenus; it may be derived from a Celtic element meaning ‘to flow’. from a short form of a Germanic personal name formed with ragin ‘advice’, ‘counsel’.
