Hibernating myocardium is the term used to describe a portion of the muscle that makes up the middle layer of heart tissue, the myocardium, that has gone into a state of dormancy due to an inadequate supply of blood. This often occurs as a result of coronary artery disease (CAD).
Is hibernating myocardium reversible?
At the cellular level, hibernating myocardium has adapted its cellular metabolism, activated cell survival genes and made morphologic cellular changes. These adaptative changes allow cell survival and are reversible if the oxygen supply returns to normal.
What is the difference between stunned and hibernating myocardium?
Definitions: Stunned myocardium is viable myocardium salvaged by coronary reperfusion that exhibits prolonged postischemic dysfunction after reperfusion. Hibernating myocardium is ischemic myocardium supplied by a narrowed coronary artery in which ischemic cells remain viable but contraction is chronically depressed.
What is takotsubo?
Takotsubo syndrome is a sudden and acute form of heart failure. Symptoms can be similar to a heart attack. It is also known as takotsubo cardiomyopathy, broken heart syndrome, acute stress induced cardiomyopathy, and apical ballooning.
What is the purpose of hibernating myocardium?
Hibernating myocardium. Hibernating myocardium is myocardial tissue that has reduced contractility due to poor perfusion, but remains viable. It is important as hibernating myocardium can recover normal contractility with revascularization.
Is hibernating myocardium a viable target for revascularization?
Hibernating myocardium represents a viable target for revascularization and should be distinguished from infarcted myocardium, where an attempt to revascularize would be futile. myocardial ischemia : rest images will demonstrate reversal of stress perfusion abnormality.
What happens to the heart when it hibernates?
In hibernating myocardium, the heart muscle cells are also not contracting, so a degree of atrophy or even dedifferentiation is not unexpected. Revascularization would therefore not expect to return function to normal immediately; rather, there would need to be time for the muscle cells to replenish their sarcomeres and regrow.
Can delayed imaging distinguish between infarction and hibernating myocardium?
On Tl-201 delayed imaging, hibernating myocardium demonstrates tracer redistribution, thus discriminating between infarction and hibernating myocardium.
